Question 1

Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate and __________________.

Accepted Answer

The answer of Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate...

Question 2

__________________ disease is caused by a genetic mutation resulting in the absence of hypoxanthine-guanine phosphoribosyltransferase.

Accepted Answer

The answer of __________________ disease is caused by a genetic...

Question 3

Some individuals with a deficiency in the enzyme adenosine deaminase exhibit __________________.

Accepted Answer

severe com...

Question 4

The synthesis of CTP from UTP requires UTP and:

Accepted Answer

A)   glutamine and ATP.
B)   glycine and ATP.
C)   glutamine, ATP, and NADH.
D)   All of the above.
E)   None of the above.F) B) and C)
G) A) and E)

Question 5

Choose the correct answer from the list below. Not all of the answers will be used.
-CTP is formed by the amination of _________________.

Accepted Answer

A)  de novo
B)  xanthylate
C)  riboflavin
D)  amino acids
E)  UTPF) N5, N10-methylenetetrahydrofolateG) nucleotideH) goutI) nucleosideJ) ATPK) urateL) salvageM) C) and D)
N) C) and J) E

Question 6

The displacing nucleophile in pyrimidine synthesis is typically:

Accepted Answer

A)   ammonia or an amino group.
B)   a metal ion.
C)   coenzyme A.
D)   All of the above.
E)   None of the above.F) A) and B)
G) B) and E)

Question 7

How is ATCase, a key enzyme in pyrimidine biosynthesis, inhibited?

Accepted Answer

ATCase is inhibited by CTP, th...

Question 8

What reaction actually forms the six-member ring found in pyrimidines?

Accepted Answer

The reaction between carbamoyl phosphate...

Question 9

Choose the correct answer from the list below. Not all of the answers will be used.
-The methyl donor to make TMP is _________________.

Accepted Answer

A)  de novo
B)  xanthylate
C)  riboflavin
D)  amino acids
E)  UTPF) N5, N10-methylenetetrahydrofolateG) nucleotideH) goutI) nucleosideJ) ATPK) urateL) salvageM) A) and C)
N) A) and H) F

Question 10

Which amino acid side chain in thymidylate synthase activates the ring of dUMP, making C-5 a good nucleophile?

Accepted Answer

A)   cysteine
B)   aspartate
C)   glutamine
D)   tyrosine
E)   serineF) A) and E)
G) A) and C)

Question 11

Choose the correct answer from the list below. Not all of the answers will be used.
-A purine or pyrimidine base linked to a sugar and to a phosphate ester is a(n)  _________________.

Accepted Answer

A)  de novo
B)  xanthylate
C)  riboflavin
D)  amino acids
E)  UTPF) N5, N10-methylenetetrahydrofolateG) nucleotideH) goutI) nucleosideJ) ATPK) urateL) salvageM) D) and L)
N) B) and I)

Question 12

Allopurinol is used to treat gout and is an inhibitor of the enzyme(s) :

Accepted Answer

A)   xanthine oxidase.
B)   xanthine hydrolase.
C)   hypoxanthine-guanine phosphoribosyltransferase.
D)   All of the above.
E)   None of the above.F) None of the above
G) B) and C)

Question 13

Fluorouracil acts as an analog of __________________.

Accepted Answer

The answer of Fluorouracil acts as an analog of __________________....

Question 14

Inosinate can be converted to:

Accepted Answer

A)   AMP.
B)   GMP.
C)   UMP.
D)   A or B.
E)   A, B, or C.F) C) and D)
G) All of the above

Question 15

How is pyrimidine biosynthesis regulated?

Accepted Answer

Pyrimidine biosynthesis is regulated by ...

Question 16

The ultimate reductant in synthesis of deoxyribonucleotides is:

Accepted Answer

A)   FADH2.
B)   NADH.
C)   NADPH.
D)   quinone.
E)   None of the above.F) B) and C)
G) C) and E)

Question 17

Choose the correct answer from the list below. Not all of the answers will be used.
-Assembly of a compound from phophoribosylpyrophosphate (PRPP)  and a base is known as a(n)  _________________ pathway.

Accepted Answer

A)  de novo
B)  xanthylate
C)  riboflavin
D)  amino acids
E)  UTPF) N5, N10-methylenetetrahydrofolateG) nucleotideH) goutI) nucleosideJ) ATPK) urateL) salvageM) A) and B)
N) F) and K)

Question 18

What are advantages of high urate levels?

Accepted Answer

Urate is a highly ef...

Question 19

The committed step in purine nucleotide biosynthesis is the conversion of __________________ to 5-phosphoribosyl-1-amine.

Accepted Answer

PRPP

Question 20

The competitive inhibitor(s)  of dihydrofolate reductase is/are:

Accepted Answer

A)   aminopterin
B)   methotrexate
C)   fluorouracil
D)   A and B
E)   B and CF) None of the above
G) A) and C)

Exam 32: Nucleotide Metabolism

Hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of guanylate and __________________.

Correct AnswerverifiedShow Answer

__________________ disease is caused by a genetic mutation resulting in the absence of hypoxanthine-guanine phosphoribosyltransferase.

Correct AnswerverifiedShow Answer

Some individuals with a deficiency in the enzyme adenosine deaminase exhibit __________________.

Correct Answerverifiedsevere com...View AnswerShow Answer

The synthesis of CTP from UTP requires UTP and:

Correct AnswerverifiedShow Answer

Choose the correct answer from the list below. Not all of the answers will be used. -CTP is formed by the amination of _________________.

Correct AnswerverifiedE

The displacing nucleophile in pyrimidine synthesis is typically:

Correct AnswerverifiedShow Answer

How is ATCase, a key enzyme in pyrimidine biosynthesis, inhibited?

Correct AnswerverifiedATCase is inhibited by CTP, th...View AnswerShow Answer

What reaction actually forms the six-member ring found in pyrimidines?

Correct AnswerverifiedThe reaction between carbamoyl phosphate...View AnswerShow Answer

Choose the correct answer from the list below. Not all of the answers will be used. -The methyl donor to make TMP is _________________.

Correct AnswerverifiedF

Which amino acid side chain in thymidylate synthase activates the ring of dUMP, making C-5 a good nucleophile?

Correct AnswerverifiedShow Answer

Choose the correct answer from the list below. Not all of the answers will be used. -A purine or pyrimidine base linked to a sugar and to a phosphate ester is a(n) _________________.

Correct AnswerverifiedShow Answer

Allopurinol is used to treat gout and is an inhibitor of the enzyme(s) :

Correct AnswerverifiedShow Answer

Fluorouracil acts as an analog of __________________.

Correct AnswerverifiedShow Answer

Inosinate can be converted to:

Correct AnswerverifiedShow Answer

How is pyrimidine biosynthesis regulated?

Correct AnswerverifiedPyrimidine biosynthesis is regulated by ...View AnswerShow Answer

The ultimate reductant in synthesis of deoxyribonucleotides is:

Correct AnswerverifiedShow Answer

Choose the correct answer from the list below. Not all of the answers will be used. -Assembly of a compound from phophoribosylpyrophosphate (PRPP) and a base is known as a(n) _________________ pathway.

Correct AnswerverifiedShow Answer

What are advantages of high urate levels?

Correct AnswerverifiedUrate is a highly ef...View AnswerShow Answer

The committed step in purine nucleotide biosynthesis is the conversion of __________________ to 5-phosphoribosyl-1-amine.

Correct AnswerverifiedPRPP

The competitive inhibitor(s) of dihydrofolate reductase is/are:

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
severe com...
View Answer

Correct Answer
verified

Correct Answer
verified
E

Correct Answer
verified

Correct Answer
verified
ATCase is inhibited by CTP, th...
View Answer

Correct Answer
verified
The reaction between carbamoyl phosphate...
View Answer

Correct Answer
verified
F

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
Pyrimidine biosynthesis is regulated by ...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
Urate is a highly ef...
View Answer

Correct Answer
verified
PRPP

Correct Answer
verified